Αλέξανδρος Γαλάρας

Arena3D 3.0: a web server for exploring, analyzing, annotating and sharing multilayered networks in 3D

Arena3D 3.0 is a web server for exploring, analyzing, and sharing multilayered biological networks in 3D with various layouts and visualization tools.

ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes

ArthroVerse compiles and annotates protein families from arthropod-associated microbiomes to explore functional diversity and host-microbe interactions.

ResLit: A Large-Scale Automated Literature Mining Database for Antimicrobial Resistance

ResLit couples BioMistral-7B screening with two-pass Qwen3-30B extraction to build an antimicrobial-resistance database of 3,120 genes and 13,593 mutations, evidence-tiered against CARD, ResFinder, and NCBI RGC.

Hepatitis B virus protein X promotes hepatocyte plasticity and survival in a differentiated human liver organoid system

This paper shows HBx promotes hepatocyte survival and reduces differentiation in human liver organoids, potentially contributing to liver cancer.

WasteFams: A database of protein families from global wastewater microbiomes

WasteFams catalogs 3,887 non-redundant protein families from wastewater metagenomes and metatranscriptomes, providing structural, taxonomic, and functional annotations for microbial function discovery.

Trithorax balances ISC fate decisions via Ptx1-mediated repression of EE specification

This study identifies Trithorax as a key factor maintaining ISC lineage fidelity by repressing EE specification through Ptx1-mediated mechanisms in Drosophila midgut.

An aerosolised dual-action Autotaxin inhibitor- PPARγ agonist for the treatment of pulmonary fibrosis

This paper introduces EL244, a dual ATX inhibitor and PPARγ agonist for treating pulmonary fibrosis, showing reduced LPA levels and fibrosis in a bleomycin model.

Invariant Natural Killer T cells control positively and negatively the development of hepatocellular carcinoma

This study shows iNKT cells both promote and inhibit hepatocellular carcinoma (HCC) development, with their role shifting from early promotion to later tumor control.

Integrative analysis of patient-derived tumoroids and ex vivo organoid modeling of ARID1A loss in bladder cancer reveals therapeutic molecular targets

The paper identifies CHEK1 and BIRC5 as therapeutic targets in ARID1A-deficient bladder cancer using patient-derived tumoroids and public datasets.