Author

Youchen Guan

Howard Hughes Medical InstituteORCID 0000-0002-6570-5293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Meng Carla WangiD· 2 shared Shihong Max GaoiD· 2 shared Aaron S. MohammediD· 1 shared Hongjie LiiD· 1 shared Lang DingiD· 1 shared Li Chen· 1 shared Qian ZhaoiD· 1 shared Qinghao ZhangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Meng Carla WangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Cell-Autonomous Cold Sensor Promotes Lipolysis Through Phase Separation

Yong Chen, Li Chen, Zezhou Zhao, Tian Lu, Youchen Guan, Zinger Yang Loureiro, Shingo Kajimura

The paper identifies a cell-intrinsic cold-sensing mechanism that enhances lipolysis through phase separation of perilipin 1 in adipose tissue.

bioRxiv · Oct 27, 2026 · PreprintCell Biology

Cross-Tissue Coordination between SLC Nucleoside Transporters Regulates Reproduction in Caenorhabditis elegans

Youchen Guan, Yong Yu, Shihong Max Gao, Lang Ding, Qian Zhao, Meng Carla Wang

This study identifies SLC29A homologs in C. elegans that mediate nucleoside coordination between soma and germline, revealing guanosine as critical for reproduction.

bioRxiv · Sep 12, 2024 · PreprintGenetics

Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies

Shihong Max Gao, Yanyan Qi, Qinghao Zhang, Aaron S. Mohammed, Yi-Tang Lee, Youchen Guan, Hongjie Li, Yusi Fu, Meng Carla Wang

This study generates single-cell transcriptomic atlases of C. elegans across its lifespan under pro-longevity conditions to identify cell-type-specific aging mechanisms and regulatory changes.

bioRxiv · Feb 28, 2023 · PreprintDevelopmental Biology