Amy Hu

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

The paper introduces WHOLISTIC, a method to image cellular activity across all organs of a vertebrate, revealing body-wide circuits and responses to stimuli.

TEMI: Tissue Expansion Mass Spectrometry Imaging

TEMI maps biomolecule distributions in tissues at single-cell resolution, revealing metabolic heterogeneity in tumors.

Deep-tissue spatial omics: imaging whole-embryo transcriptomics and subcellular structures at high spatial resolution

This paper introduces cycleHCR technology for high-resolution spatial transcriptomics and protein imaging in thick tissues, demonstrating its application in mouse embryos and brain slices.

Rapid reconstruction of neural circuits using tissue expansion and lattice light sheet microscopy

The paper develops a method to rapidly reconstruct neural circuits with single synapse resolution using tissue expansion and lattice light sheet microscopy, validated in Drosophila.

Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

The paper shows nitric oxide acts as a cotransmitter in dopaminergic neurons to modulate memory dynamics in Drosophila.

Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo

The paper presents transgenic mice expressing the red calcium indicator jRGECO1a for in vivo neuronal imaging, showing comparable or better signal-to-noise ratios than viral methods.

Sensitive red protein calcium indicators for imaging neural activity

The paper introduces improved red calcium indicators that match the sensitivity of GFP-based indicators, enabling better in vivo neural activity imaging.