Yifan Yang

ROR2 drives right ventricular heart failure via disruption of proteostasis

This study identifies ROR2 as a driver of right ventricular failure by disrupting proteostasis, showing that modulating ROR2 can rescue structural and functional deficits in cardiomyocytes.

A postnatal human lung developmental atlas reveals windows of genetic vulnerability to chronic lung disease

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

Mechanism of action of Buqing Granule against Diabetic retinopathy based on network pharmacology and animal experiments

This study uses network pharmacology and animal experiments to identify key components and targets of Buqing Granule in treating diabetic retinopathy.

Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes

This study evaluates the durability of epigenome editing for reducing gene expression in cardiovascular disease targets, finding durable effects for PCSK9 but not for ANGPTL3 or AGT.