A simple liquid 3D cell culture paradigm models oxidative mitochondrial metabolism of epithelial breast cancer cells with relevance for lung metastases.
Kuppusamy Balamurugan, Melissa R. Mikolaj, Jonathan M. Weiss, Ronald J. Holewinski, Yu Fan, Shiba Prasad Dash, Xia Xu, Lois McKennett, Christopher W. Dell, Duncan E. Donohue, Ariana Vitale, Shashikala Ratnayake, Shikha Sharan, Qingrong Chen, Daoud M. Meerzaman, , Esta Sterneck
This paper compares two 3D culture models for breast cancer cells, finding that the EmC model better mimics lung metastasis by altering metabolism and gene expression.
Cancer Research Communications · Feb 18, 2026Peer-reviewedCancer Biology