Duncan E. Donohue

Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP-dependent pyruvate carboxylase expression

This study identifies E-cadherin/YAP-dependent pyruvate carboxylase expression as a metabolic driver of breast cancer progression and metastasis, with therapeutic implications for epithelial TNBC.

A simple liquid 3D cell culture paradigm models oxidative mitochondrial metabolism of epithelial breast cancer cells with relevance for lung metastases.

This paper compares two 3D culture models for breast cancer cells, finding that the EmC model better mimics lung metastasis by altering metabolism and gene expression.