Isabelle Brunet

Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice

This study identifies vascular dysfunction as a key contributor to oxaliplatin-induced peripheral neuropathy in mice by showing increased vasoconstriction and hypoxia, which can be mitigated by vasodilators.

Clearing method adapted to FFPE tissues for 3D imaging of nerve fibers, B cells, and tertiary lymphoid structures

The paper introduces miDISCO+, a modified clearing method for FFPE tissues, enabling 3D imaging of nerve fibers, B cells, and tertiary lymphoid structures in single samples.

Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain

The paper identifies and characterizes LYVE-1+ perivascular macrophages in the mouse brain, showing their regional distribution, developmental dynamics, and reduced density in Alzheimer's disease model.

Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve

The paper investigates the role of Netrin-1 and myelinating Schwann cells in regulating vascularization of the developing mouse sciatic nerve, showing Netrin-1 promotes vascular invasion during embryogenesis while Schwann cells reduce it postnatally.

Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.