Author

David Viterbo

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 3 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Guy‐Franck RichardiD· 4 shared Stéphane Descorps-DeclèreiD· 3 shared Lucie PoggiiD· 2 shared Valentine MosbachiD· 2 shared Arnaud F. KleiniD· 1 shared Bernard DujoniD· 1 shared Brendan P. CormackiD· 1 shared Bruno Dumas· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersGenetics

Guy‐Franck RichardORCID

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4 papers

Recent·Most cited

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cells

David Viterbo, Dupaigne Pauline, Pierre Alexandre Kaminski, François Déjardin, Stéphane Pêtres, Éric Le Cam, Guy‐Franck Richard

The paper shows that CTG trinucleotide repeats form imperfect hairpin structures in living cells, specifically as heteroduplex DNA molecules.

bioRxiv · Jun 4, 2024 · PreprintMolecular Biology

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cells

Laureline Bétemps, Stéphane Descorps-Declère, Olivia Frenoy, Lucie Poggi, Valentine Mosbach, Stéphanie Tomé, David Viterbo, Arnaud F. Klein, Laurence Ma, Sonia Lameiras, Thomas Cokelaer, Marc Monot, Bruno Dumas, Geneviève Gourdon, Denis Furling, Guy‐Franck Richard

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

bioRxiv · Oct 14, 2023 · PreprintGenomics

Functional variability in adhesion and flocculation of yeast megasatellite genes

Cyril Saguez, David Viterbo, Stéphane Descorps‐Declère, Brendan P. Cormack, Bernard Dujon, Guy‐Franck Richard

The paper investigates the functional roles of megasatellites in yeast adhesion and flocculation by deleting genes and evolving strains.

Genetics · Mar 11, 2022Peer-reviewedGenetics

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangements

Valentine Mosbach, David Viterbo, Stéphane Descorps‐Declère, Lucie Poggi, Wilhelm Vaysse-Zinkhöfer, Guy‐Franck Richard

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.

PLoS Genetics · Jul 16, 2020Peer-reviewedGenetics