Author

Guy‐Franck Richard

Centre National de la Recherche ScientifiqueORCID 0000-0002-8233-3532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:yeast· 4 Assay:CRISPR screen· 2 Research Focus:perturbation response prediction· 2 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

David Viterbo· 4 shared Stéphane Descorps-DeclèreiD· 4 shared Lucie PoggiiD· 3 shared Bruno Dumas· 2 shared Valentine MosbachiD· 2 shared Arnaud F. KleiniD· 1 shared Bernard DujoniD· 1 shared Brendan P. CormackiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersGenetics

David Viterbo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cells

David Viterbo, Dupaigne Pauline, Pierre Alexandre Kaminski, François Déjardin, Stéphane Pêtres, Éric Le Cam, Guy‐Franck Richard

The paper shows that CTG trinucleotide repeats form imperfect hairpin structures in living cells, specifically as heteroduplex DNA molecules.

bioRxiv · Jun 4, 2024 · PreprintMolecular Biology

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cells

Laureline Bétemps, Stéphane Descorps-Declère, Olivia Frenoy, Lucie Poggi, Valentine Mosbach, Stéphanie Tomé, David Viterbo, Arnaud F. Klein, Laurence Ma, Sonia Lameiras, Thomas Cokelaer, Marc Monot, Bruno Dumas, Geneviève Gourdon, Denis Furling, Guy‐Franck Richard

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

bioRxiv · Oct 14, 2023 · PreprintGenomics

Functional variability in adhesion and flocculation of yeast megasatellite genes

Cyril Saguez, David Viterbo, Stéphane Descorps‐Declère, Brendan P. Cormack, Bernard Dujon, Guy‐Franck Richard

The paper investigates the functional roles of megasatellites in yeast adhesion and flocculation by deleting genes and evolving strains.

Genetics · Mar 11, 2022Peer-reviewedGenetics

Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations

Lucie Poggi, Lisa Emmenegger, Stéphane Descorps‐Declère, Bruno Dumas, Guy‐Franck Richard

The paper evaluates the efficacy of CRISPR-Cas nucleases on microsatellites linked to human disorders, identifying variations in cleavage efficiency and off-target mutations.

Nucleic Acids Research · Jul 6, 2021Peer-reviewedGenetics

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangements

Valentine Mosbach, David Viterbo, Stéphane Descorps‐Declère, Lucie Poggi, Wilhelm Vaysse-Zinkhöfer, Guy‐Franck Richard

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.

PLoS Genetics · Jul 16, 2020Peer-reviewedGenetics