Author

Lucie Poggi

Centre National de la Recherche ScientifiqueORCID 0000-0002-8229-2339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:perturbation response prediction· 2 Organism:yeast· 2 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Guy‐Franck RichardiD· 3 shared Stéphane Descorps-DeclèreiD· 3 shared Bruno Dumas· 2 shared David Viterbo· 2 shared Valentine MosbachiD· 2 shared Arnaud F. KleiniD· 1 shared Denis FurlingiD· 1 shared Geneviève GourdoniD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Guy‐Franck RichardORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 14, 2023

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cells

Laureline Bétemps, Stéphane Descorps-Declère, Olivia Frenoy…·Guy‐Franck Richard

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

4 citations

humanwhole-genome sequencing

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GeneticsNucleic Acids ResearchPeer-reviewedJul 6, 2021

Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations

Lucie Poggi, Lisa Emmenegger, Stéphane Descorps‐Declère…·Guy‐Franck Richard

The paper evaluates the efficacy of CRISPR-Cas nucleases on microsatellites linked to human disorders, identifying variations in cleavage efficiency and off-target mutations.

8 citations

yeastCRISPR screen

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GeneticsPLoS GeneticsPeer-reviewedJul 16, 2020

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangements

Valentine Mosbach, David Viterbo, Stéphane Descorps‐Declère…·Guy‐Franck Richard

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.

20 citations

yeastCRISPR screen

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