Leighton H. Duncan

This study investigates the role of Sox8 and Sox9 in retinal Muller glia differentiation and nuclear positioning using genetic and single-cell multiomic approaches.

This study identifies gene regulatory networks controlling hypothalamic and prethalamic development using single-cell RNA and ATAC sequencing in mice, revealing key transcription factors and their roles in metabolic and cognitive traits.

This study compares single-cell and single-nucleus RNA-seq in a rabbit PVR model, finding similar gene expression profiles but differences in cell type capture rates and fibrotic cell representation.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

This study identifies NFI factors as repressors of tanycyte-derived neurogenesis and shows their disruption promotes proliferation and neurogenesis in the hypothalamus.

The paper uses diffusion condensation to analyze the C. elegans nerve ring neuropil, revealing its stratified structure and developmental principles.