Author

David R O’Leary

Washington University in St. LouisORCID 0000-0002-5757-5150Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Abby M. GreeniD· 1 shared Aishwarya KrishnaniD· 1 shared Alessandro VindigniiD· 1 shared Alice MeroniiD· 1 shared Andrew L. YoungiD· 1 shared Ava R. HanseniD· 1 shared Brooke R. Harris· 1 shared Dylan F. FingermaniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Abby M. GreenORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 23, 2025

JAK2V617F Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones

Tyler M. Parsons, Aishwarya Krishnan, Infencia Xavier Raj…·Grant Anthony Challen

This study shows that leukemic clones can evolve independently of JAK2V617F in MPNs and contribute to disease progression through pro-inflammatory environments.

DOI 10.1101/2025.09.23.678057

humanexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintNov 28, 2023

The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress

David R O’Leary, Ava R. Hansen, Dylan F. Fingerman…·Abby M. Green

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.

DOI 10.1101/2023.11.28.568952

humanexperimental assay

𝕏 PostBluesky