Author

Brooke R. Harris

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Abby M. GreeniD· 3 shared Dylan F. FingermaniD· 2 shared Jeffrey J. BednarskiiD· 2 shared Rachel A. DeWeerdiD· 2 shared Alessandro VindigniiD· 1 shared Alice MeroniiD· 1 shared Ambrocio SancheziD· 1 shared Ava R. HanseniD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Abby M. GreenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping

Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R. Harris, Josefine Striepen, John Maciejowski, Abby M. Green, Rémi Buisson

This study identifies APOBEC3B as the enzyme responsible for ssDNA breakage during replication catastrophe induced by ATR inhibition, revealing a mechanism for PARP1 trapping and synthetic lethality with PARP inhibitors.

Science Advances · Apr 16, 2025Peer-reviewedMolecular Biology

APOBEC3A drives metastasis of ovarian cancer by altering epithelial-to-mesenchymal transition

Jessica Merritt Devenport, Thi Tran, Brooke R. Harris, Dylan F. Fingerman, Rachel A. DeWeerd, Lojain H Elkhidir, Danielle LaVigne, Katherine Cynthia Fuh, Lulu Sun, Jeffrey J. Bednarski, Ronny Drapkin, Mary Margaret Mullen, Abby M. Green

This study shows APOBEC3A promotes ovarian cancer metastasis by altering epithelial-to-mesenchymal transition in high-grade serous ovarian cancer.

JCI Insight · Mar 9, 2025Peer-reviewedCancer Biology

The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress

David R O’Leary, Ava R. Hansen, Dylan F. Fingerman, Thi Tra My Tran, Brooke R. Harris, Katharina E. Hayer, Jiayi Fan, Emily Chen, Mithila Tennakoon, Rachel A. DeWeerd, Alice Meroni, Julia H. Szeto, Matthew D. Weitzman, Ophir Shalem, Jeffrey J. Bednarski, , Abby M. Green

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.

bioRxiv · Nov 28, 2023 · PreprintMolecular Biology