The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress
David R O’Leary, Ava R. Hansen, Dylan F. Fingerman, Thi Tra My Tran, Brooke R. Harris, Katharina E. Hayer, Jiayi Fan, Emily Chen, Mithila Tennakoon, Rachel A. DeWeerd, Alice Meroni, Julia H. Szeto, Matthew D. Weitzman, Ophir Shalem, Jeffrey J. Bednarski, , Abby M. Green
This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.
bioRxiv · Nov 28, 2023 · PreprintMolecular Biology