Author

Lei Yao

Buck Institute for Research on AgingORCID 0000-0002-5780-5809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alissa L. NanaiD· 2 shared Grant Kauwe· 2 shared Jackson H. Chen· 2 shared Kristeen A. Pareja-Navarro· 2 shared Lea T. GrinbergiD· 2 shared Li GaniD· 2 shared Salvatore SpinaiD· 2 shared Tara E. TracyiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alissa L. NanaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis

Grant Kauwe, Doyle Lokitiyakul, Ivy L. Wong, Kevin Schneider, Varun Sridhar, Durai Sellegounder, Yani Y. Ngwala, Lei Yao, Jackson H. Chen, Kristeen A. Pareja-Navarro, Alissa L. Nana, Salvatore Spina, William W. Seeley, Lea T. Grinberg, Eric M. Verdin, , Tara E. Tracy

bioRxiv · Sep 11, 2025 · PreprintNeuroscience

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Grant Kauwe, Kristeen A. Pareja-Navarro, Lei Yao, Jackson H. Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L. Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Joel H. Kramer, , Tara E. Tracy

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

Journal of Clinical Investigation · Feb 1, 2024Peer-reviewedNeuroscience

Genome charaterization based on the Spike-614 and NS8-84 loci of SARS-CoV-2 reveals two major onsets of the COVID-19 pandemic

Xiaowen Hu, Yaojia Mu, Ruru Deng, Guohui Yi, Lei Yao, Jiaming Zhang

This study analyzes SARS-CoV-2 genomes to identify two major pandemic onsets driven by different haplotypes, DL in China and GL globally.

bioRxiv · Dec 4, 2022 · PreprintBioinformatics