Dieter Edbauer

Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control

The paper compares CRISPRi screens in human stem cells and their derivatives to show cell type-dependent roles of translation-coupled quality control factors.

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding

This study shows that TDP-43 and Tau directly interact, promoting co-condensation but reducing Tau fibril formation and seeding.

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration

This study shows that reduced progranulin leads to increased legumain activity, which promotes TDP-43 pathology in FTLD, suggesting legumain as a therapeutic target.

Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

The paper performs a multiomic analysis of ALS patients and mouse models to identify sex differences, molecular subclusters, and the MAPK pathway as a therapeutic target.

Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin

Peripheral AAV-mediated delivery of brain-penetrant PGRN rescues TDP-43 pathology, neurodegeneration and motor phenotypes in FTLD-GRN models.

Gel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes in neurons

This study identifies TDP-25 inclusions as sequestering proteasomes, leading to proteostasis impairment in ALS/FTD.

RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment

The paper shows that environmental enrichment in adult male mice enhances synaptic plasticity, which is inherited by offspring via sperm RNA, specifically microRNAs 212/132.