Lindsay A. Hohsfield

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.

Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff disease

This study shows that myeloid-derived β-hexosaminidase supports neuronal lysosomal function and that microglial replacement can reverse Sandhoff disease symptoms.