Jürgen Fripp

Shared genetic architecture between brain iron deposition and Alzheimer's disease

This study identifies shared genetic factors between brain iron deposition and Alzheimer's disease, revealing a polygenic basis and potential neuroimmune mechanisms.

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

The paper shows that cholinergic basal forebrain neurons influence vascular-CSF coupling and glymphatic flux in mice, suggesting a neurovascular mechanism for waste clearance in the brain.

Multi T1-weighted contrast imaging and T1 mapping with Compressed sensing FLAWS at 3T

This paper optimizes the FLAWS MRI sequence with compressed sensing to reduce acquisition time while maintaining image quality and enables T1-weighted imaging and mapping at 3T.

Novel genomic loci and pathways influence patterns of structural covariance in the human brain

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

Avoiding Data Loss: Synthetic MRIs Generated from Diffusion Imaging Can Replace Corrupted Structural Acquisitions For Freesurfer-Seeded Tractography

The paper proposes generating synthetic structural MRI images from diffusion data to replace corrupted ones, enabling Freesurfer-seeded tractography with high accuracy.

A snapshot of brain and cognition in healthy mid-life and older adults

The paper examines cognitive and brain morphology changes from mid-life to older adulthood, finding age-related shifts in cognitive domains and sulcal width patterns.

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's Disease

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.

Harmonization of large multi-site imaging datasets: Application to 10,232 MRIs for the analysis of imaging patterns of structural brain change throughout the lifespan

The paper harmonizes 10,232 structural brain MRIs from 18 studies to create a normative reference of brain development and aging across 3 to 96 years.

Non-Linear Realignment Improves Hippocampus Subfield Segmentation

This paper improves hippocampus subfield segmentation by using non-linear realignment to reduce movement artefacts and enhance image quality in MR scans.