Joseph C. Wu

The paper uses transcriptomic data to identify potential drug therapies for a monogenic disease by finding FDA-approved drugs with similar transcriptional profiles.

This study compares two allele-specific silencing strategies in a human model of hypertrophic cardiomyopathy, finding that reducing both alleles improves contractility more than targeting only the disease allele.

This paper demonstrates that chimpanzee iPSCs can form cross-species chimeras with rhesus macaque embryos, suggesting functional similarity between human and chimpanzee cells.

The paper identifies high-priority proteins across the human diseasome using semantic similarity and provides a systematic collection of popular proteins across diseases, phenotypes, and pathways.