Lenka Hernychová

Uncovering Functional Distant Mutations by Ultra-High-Throughput Screening of Dehalogenases

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

Structural mechanism governing radiationless energy transfer in Renilla bioluminescence

This study reports co-crystal structures of a bioluminescent energy-transfer complex in Renilla reniformis, revealing the spatial arrangement of donor-acceptor chromophores and their role in efficient radiationless energy transfer.

Open or closed? Exploring the conformational heterogeneity of human plasminogen across multiple resolution scales

This study characterizes the conformational states of human plasminogen using structural biology techniques, revealing closed and open conformations in recombinant and plasma-derived variants.

Taurine Inhibits Apolipoprotein E4 Aggregation

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

Investigating the Conformational Flexibility of Staphylokinase Across Multiple Time Scales

This study investigates the conformational flexibility of staphylokinase variants to explain their reduced immunogenicity and altered properties.

Multi-omics integration in Esophageal Adenocarcinoma reveals therapeutic targets and EAC-specific regulation of protein abundances

The paper identifies GPA33 as an EAC-specific biomarker and reveals post-transcriptional regulation of protein expression in EAC through multi-omics integration.

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Reduction by Alzheimer's Disease Drug Candidate

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.