Gordon L. Hager

QuantiTrack: A unified software to study protein dynamics in living cells

QuantiTrack, a MATLAB GUI, unifies single-molecule detection, tracking, quality control and mobility analyses; for glucocorticoid receptor, hormone washout cut bound fraction, dwell times and low-mobility occupancy.

Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation

The paper defines a temporally resolved framework for GR-mediated gene regulation, identifying three binding classes and their functional links to transcriptional output.

A Novel Patient-Derived Mutation in Glucocorticoid Receptor Reveals an Essential Role for DNA binding in Development and Endocrine Regulation

The paper identifies a novel GR mutation causing partial glucocorticoid resistance and shows its impact on development and endocrine regulation through patient-derived cells and a knock-in mouse model.

The multimerization pathway of the glucocorticoid receptor

The paper presents a new crystal structure of agonist-bound GR-LBD and proposes a model for GR multimerization, reconciling structural and functional data on glucocorticoid resistance.

Bile acids target an exposed cavity in the glucocorticoid receptor modulating receptor self-assembly, chromatin binding and transcriptional activity

This study shows bile acids bind to an exposed cavity on the glucocorticoid receptor, affecting its self-assembly and transcriptional activity.

Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

The Glucocorticoid Receptor is Required for Efficient Aldosterone-Induced Transcription by the Mineralocorticoid Receptor

This study shows that GR co-expression enhances MR transcriptional activity in response to aldosterone, even without glucocorticoids.