Robert H. Edwards

An extracellular substrate for the temporary storage of memories

The paper identifies aggrecan as an extracellular matrix protein that stabilizes fear memories by altering neuronal excitability in the hippocampal dentate gyrus.

The impact of alpha synuclein overexpression on nigrostriatal transmission

This study investigates how overexpression of wild type alpha synuclein affects nigrostriatal neurotransmission in Parkinson's disease, finding selective deficits in dopamine and glutamate release.

Synaptic vesicles that store monoamines and glutamate differ in protein composition.

This study compares synaptic vesicle protein composition between dopamine and glutamate release sites, identifying differences in abundance and function that affect recycling kinetics.

Overexpression of alpha synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice

Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine

This study identifies AP-3 and VPS41 as factors that promote high-frequency dopamine release by targeting VMAT2 to axons and producing specialized synaptic vesicles.

Input-specific control of interneuron numbers in nascent striatal networks

The paper identifies input-specific mechanisms regulating the survival of two striatal interneuron subtypes during programmed cell death.

α-Synuclein facilitates dopamine release during burst firing of substantia nigra neurons in vivo

This study shows α-synuclein enhances dopamine release during burst firing in substantia nigra neurons in vivo, independent of β- and γ-synucleins or presynaptic calcium.