Alexander Brehm

Targeted degradation of Drosophila FOG homolog U-shaped mimics macrophage transdifferentiation in S2 cells

The paper shows that degrading U-shaped in Drosophila S2 cells reprograms them to a lamellocyte-like state, mimicking macrophage transdifferentiation.

Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation

The paper identifies hangover's role in regulating gene expression by inhibiting NSL-mediated H4K16 acetylation at transcriptional start sites in Drosophila.

RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling

The paper shows RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling by competing with nucleosome substrates, suggesting an evolutionary conserved mechanism.

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

This study identifies Ush's role in regulating gene expression, metabolism, and cell cycle in Drosophila hematopoiesis through its interaction with the NuRD complex.