Olalla Vázquez

Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA decarbonylase/synthase

The paper investigates the structure and dynamics of the archaeal ACDS complex, revealing a mechanism for efficient carbon transfer through transient interactions rather than stable complexes.

Chemically tunable permeability of engineered alpha-Hemolysin in synthetic cells

This paper develops a method to tune nanopore permeability using chemically modified alpha-hemolysin in synthetic cells.

Short internal open reading frames regulate the translation of N-terminally truncated proteoforms

The paper identifies internal short open reading frames (sORFs) that repress the translation of N-terminally truncated proteoforms, including nTRIP6, and shows this regulation is context-dependent.

ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner

This study identifies ZNF512B as a repressor of gene expression that interacts with the NuRD complex via a conserved motif and can cause chromatin aggregation independently of NuRD.

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Autoencoder design plus a roughly 24-hour cell-free screen tested 500 candidates over five rounds, finding 30 functional AMPs; six were broad-spectrum with no resistance emerging in E. coli.

RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling

The paper shows RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling by competing with nucleosome substrates, suggesting an evolutionary conserved mechanism.

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

This study identifies Ush's role in regulating gene expression, metabolism, and cell cycle in Drosophila hematopoiesis through its interaction with the NuRD complex.