Author

Yichen Zhong

The University of SydneyORCID 0000-0002-2644-5329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Organism:Drosophila· 1

Frequent Co-Authors

Joel P. MackayiD· 3 shared Xavier J. Reid· 2 shared Alastair G. StewartiD· 1 shared Alexander BrehmiD· 1 shared Andrea DanersiD· 1 shared Andrea NistiD· 1 shared Cameron Taylor· 1 shared Chandrika N. DeshpandeiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

Joel P. MackayORCID

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3 papers

Recent·Most cited

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation

L. Lambrechts, Xavier J. Reid, Lucas Kambanis, Clement Luong, Erekle Kobakhidze, Andrea Daners, Yichen Zhong, Karishma Patel, Charlotte Franck, Hakimeh Moghaddas Sani, Cameron Taylor, J. Low, Richard J. Payne, Joel P. Mackay

This study investigates BRD4's nucleosomal binding affinity and shows that histone acetylation modestly enhances this interaction, with little dependence on acetylation pattern.

Nucleic Acids Research · Nov 26, 2025Peer-reviewedBiochemistry

The structure and composition of native human nucleosomes

Xavier J. Reid, Meghna Sobti, Yi C. Zeng, Yichen Zhong, Chandrika N. Deshpande, Paul Young, Simon H. J. Brown, Jason K. K. Low, Alastair G. Stewart, Joel P. Mackay

This study reports the high-resolution cryo-EM structure of native human nucleosomes from HEK293 cells and provides mass spectrometry analysis of histone modifications.

bioRxiv · Oct 10, 2025 · PreprintBiochemistry

RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling

Ikram Ullah, Clemens Thölken, Yichen Zhong, Mara John, Oliver Roßbach, Jonathan Lenz, Markus Großringer, Andrea Nist, Lea Albert, Thorsten Stiewe, Roland Hartmann, Olalla Vázquez, Ho-Ryung Chung, Joel P. Mackay, Alexander Brehm

The paper shows RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling by competing with nucleosome substrates, suggesting an evolutionary conserved mechanism.

bioRxiv · Jun 3, 2021 · PreprintMolecular Biology