The paper introduces PeCorA, a method to detect discordant peptide quantities in shotgun proteomics data, identifying 15% of proteins with one discordant peptide in mouse microglia.

Journal of Proteome Research · Dec 16, 2020Peer-reviewedBioinformatics

eEF1A2 controls local translation and actin dynamics in structural synaptic plasticity

Mònica B. Mendoza, Sara Gutierrez, Raúl Ortiz, David F. Moreno, Maria Dermit, Martin Dodel, Elena Rebollo, Miquel Bosch, Faraz K. Mardakheh, Carme Gallego

This study shows that phosphorylation of eEF1A2 modulates local translation and actin dynamics, influencing structural synaptic plasticity through interactions with GEF proteins and metabotropic glutamate receptor signaling.

bioRxiv · Oct 20, 2020 · PreprintNeuroscience

RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon

Johnny X. Yu, Albertas Navickas, Hosseinali Asgharian, Bruce Culbertson, Lisa Fish, Kristle Garcia, John Paolo Olegario, Maria Dermit, Martin Dodel, Benjamin Hänisch, Yikai Luo, Ethan M. Weinberg, Rodrigo Dienstmann, Robert S. Warren, Faraz K. Mardakheh, Hani Goodarzi

The paper identifies RBMS1 as a suppressor of colon cancer metastasis by stabilizing its mRNA targets, showing its clinical relevance in patient survival.

Cancer Discovery · Jun 8, 2020Peer-reviewedSystems Biology