David F. Moreno

Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cells

This study shows Srs2 in yeast and PARI in human cells delay abscission to prevent chromatin bridge damage during cytokinesis.

Gene-specific RNA homeostasis revealed by perturbation of coactivator complexes

The paper shows that TIP60 depletion alters transcription and is offset by changes in RNA export and stability, revealing gene-specific transcript buffering mechanisms.

eEF1A2 controls local translation and actin dynamics in structural synaptic plasticity

This study shows that phosphorylation of eEF1A2 modulates local translation and actin dynamics, influencing structural synaptic plasticity through interactions with GEF proteins and metabotropic glutamate receptor signaling.

Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1

The paper challenges a model proposing that protein synthesis increases in pre-Start G1, finding that Whi5 concentration remains constant and Cln3 increase is not due to synthesis.

The chaperone-client network subordinates cell-cycle entry to growth and stress

This study identifies chaperone systems as limiting factors for cell-cycle entry, showing their role in regulating nuclear accumulation of the G1 Cdk-cyclin complex and linking cell-cycle progression to growth and stress conditions.