Nicolas Gambardella Le Novère

The paper develops a deep learning model combining clinical data, gene expression, and DNA methylation to distinguish NASH from steatosis and identifies new genes involved in liver disease severity.

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

This study uses a computational model to show neurogranin regulates synaptic plasticity by modulating calmodulin's interaction with CaMKII and CaN at different calcium spike frequencies.

This study uses live imaging and mathematical modeling to analyze ATG13 dynamics in non-selective autophagy and mitophagy, revealing distinct patterns of translocation and their relationship to mitochondrial fragment size.

The paper outlines ten lessons for designing, provisioning, and reusing persistent identifiers to improve data integration in life sciences.

SBpipe automates repetitive simulation and analysis tasks in Systems Biology, generating reports and enabling parameter estimation and robustness analysis.