Thomas A. Rando

In vivo self-renewal and expansion of quiescent stem cells from a non-human primate

The paper identifies and characterizes quiescent stem cells in a non-human primate, showing their in vivo self-renewal and similarity to human cells.

Spatiotemporal transcriptomic profiling and modeling of mouse brain at single-cell resolution reveals cell proximity effects of aging and rejuvenation

The paper develops spatial aging clocks to analyze cell proximity effects in mouse brain aging and rejuvenation, revealing pro-aging and pro-rejuvenating influences of specific cell types.

A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis

The paper develops a deep learning platform to screen compounds for ALS treatment using age-relevant human motor neurons and identifies NCB-0846 as a potential therapeutic.

Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain

This study develops cell type-specific aging clocks using single-cell transcriptomic data to quantify aging and rejuvenation in the brain's neurogenic regions.

RNA-BINDING PROTEINS DIRECT MYOGENIC CELL FATE DECISIONS

The paper identifies Hnrnpa2b1 as a key RBP regulating myogenic differentiation through post-transcriptional control in skeletal muscle regeneration.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism

The paper creates a comprehensive cell atlas of mouse lemurs using single-cell RNA sequencing, identifying over 750 cell types and comparing their molecular profiles to humans, mice, and macaques.

Exercise and angiotensin receptor blockade enhance recovery after orthopaedic trauma in mice by decreasing pain and improving muscle regeneration

This study shows that delayed exercise and losartan treatment improve recovery after orthopaedic trauma in mice by reducing pain and muscle fibrosis.

Exercise conditioned plasma dampens inflammation via clusterin and boosts memory

The paper shows that plasma from exercising mice reduces brain inflammation and improves memory, with clusterin as a key anti-inflammatory factor also elevated in human exercisers.

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

The paper creates a single-cell transcriptomic atlas of 20 mouse organs and tissues, providing a resource for studying gene expression across cell types.