Joost Verhaagen

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease

The paper identifies reduced triacylglycerols and lipid droplets in resilient Alzheimer's donors compared to AD patients, using multi-omics analysis of brain tissue.

Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

This study shows that stabilizing V1 interneuron-motor neuron connectivity in ALS mice improves motor function by enhancing motor neuron survival.

Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract

This study shows that increasing PI3K{delta} activity in adult rat cortical neurons promotes corticospinal tract regeneration and functional recovery after spinal cord injury.

Alpha 9 integrin expression enables reconstruction of the spinal cord sensory pathway.

This paper demonstrates that expressing alpha 9 integrin and its activator kindlin-1 in sensory neurons enables axon regeneration through spinal cord injuries in rats, restoring sensory function.

ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons

ORANGE enables targeted genomic integration of fluorescent tags in neurons to study endogenous protein distribution with high-resolution imaging.

Cerebellar plasticity and associative memories are controlled by perineuronal nets

This study shows that perineuronal nets in the deep cerebellar nuclei are involved in regulating cerebellar plasticity and associative memory through structural and functional changes during eyeblink conditioning.

Restoring the pattern of perineuronal net sulphation corrects age-related memory loss

The paper shows that restoring C6S levels in aged brains improves memory by reversing perineuronal net inhibition.