Fred de Winter

This study shows that Purkinje cell intrinsic activity before synaptic maturation is critical for dendrite growth, connectivity, and cerebellar function, with early disruptions causing severe morphological and functional defects.

This study shows that long-term PI3Kδ overexpression in adult rat cortex using AAV1 is safe and well-tolerated, with no adverse effects observed over one year.

This study investigates the combined effects of db-cAMP and integrin 9 overexpression on axonal regeneration in spinal cord injury models, finding mixed in vitro and in vivo results.

This paper demonstrates that expressing alpha 9 integrin and its activator kindlin-1 in sensory neurons enables axon regeneration through spinal cord injuries in rats, restoring sensory function.

ORANGE enables targeted genomic integration of fluorescent tags in neurons to study endogenous protein distribution with high-resolution imaging.

This study shows that perineuronal nets in the deep cerebellar nuclei are involved in regulating cerebellar plasticity and associative memory through structural and functional changes during eyeblink conditioning.

The paper shows that inhibitory signaling shapes spontaneous activity patterns in the developing visual cortex by modulating cell recruitment and event spread.