Enrico Gratton

ESPRESSO provides high-dimensional spatiotemporal phenotyping of organelles using fluorescent labeling and advanced microscopy, enabling analysis of cell states, stress response, and immune cell polarization.

This paper introduces a Bayesian S-FLIM framework that learns spectra and lifetimes photon-by-photon, enabling efficient deconvolution of up to 9 fluorophore species with overlapping spectra.

The paper introduces an organelle phenotyping approach using live-cell microscopy to identify C1q as a regulator of microglial function, showing its role in fatty acid storage and mitochondrial membrane potential.

The paper uses single-cell transcriptomics to define basal cell states in skin homeostasis and wound healing, identifying distinct transcriptional states and their dynamics.

This study identifies Syncrip/hnRNPQ as a regulator of activity-induced Msp300/Nesprin-1 expression and new synapse formation through local translation.