Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation
Christopher William Schultz, Sourav Taru Saha, Anjali Dhall, Yang Zhang, Parth Anil Desai, Lőrinc Sándor Pongor, David A. Scheiblin, Valentin Magidson, Yilun Sun, Christophe E. Redon, Suresh Kumar, Manan Krishnamurthy, Henrique Bregolin Dias, Vasilisa Aksenova, Elizabeth G Giordano, , Anish Thomas
This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.
bioRxiv · Apr 29, 2025 · PreprintCancer Biology