Manan Krishnamurthy

This study identifies key cellular programs and pathways driving metastatic organotropism in small cell lung cancer using preclinical models and multiomic profiling.

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

This study shows the Drosophila Pol θ linker domain is essential for DNA repair and development, with its function dependent on specific amino acid properties rather than protein interactions.

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

This study shows that GR co-expression enhances MR transcriptional activity in response to aldosterone, even without glucocorticoids.

This study shows Drosophila Rif1 is not essential for general DNA damage repair but is critical for P-element excision-induced double-strand break repair and influences pathway choice by suppressing homologous recombination and promoting single-strand annealing.