This study identifies genetic, intrinsic, and environmental factors influencing innate immune cytokine responses in four-year-old children, finding strong genetic and inflammatory biomarker associations.

bioRxiv · May 5, 2026 · PreprintImmunology

Prenatal Environmental Determinants of Aromatase Brain-Promoter Methylation in Cord Blood: Chemical, Airborne, Pharmacological, and Nutritional Factors

Samuel Tanner, Katherine D. Drummond, Sarah M Thomson, Kristina Vacy, Christos Symeonides, Boris Novakovic, Toby Mansell, Martin O’Hely, Richard Saffery, Mimi L.K. Tang, Peter David Sly, Peter Vuillermin, the BIS Investigator Group, Wah Chin Boon, Chol‐Hee Jung, , Anne‐Louise Ponsonby

The paper examines prenatal environmental factors affecting CYP19A1 promoter methylation in cord blood using WQS regression, finding associations with bisphenols, sunlight, mould, phthalates, folate, and air pollution.

Current Zoology · Jan 1, 2026Peer-reviewedGenomics

Prenatal DEHP plastic chemical exposure increases the likelihood of child autism and ADHD symptoms through epigenetic programming

Samuel Tanner, Alex Eisner, Boris Novakovic, Lada Holland, Toby Mansell, Gillian England-Mason, Sarah M. Merrill, Deborah Dewey, Martin O’Hely, Christos Symeonides, Richard Saffery, Jochen F. Mueller, Mimi L.K. Tang, Peter David Sly, Peter Vuillermin, , Anne‐Louise Ponsonby

This study shows prenatal DEHP exposure increases ASD and ADHD symptoms through DNA methylation changes in children.

bioRxiv · Mar 3, 2025 · PreprintNeuroscience

A genome catalog of the early-life human skin microbiome

Zeyang Shen, Lukian Robert, Milan Stolpman, You Che, Katrina Jane Allen, Richard Saffery, Audrey Walsh, Angela Young, Jana Eckert, Clay Deming, Qiong Chen, Sean Conlan, Karen Laky, Jenny Min Li, Lindsay Chatman, , Carrie Service

The paper presents a genome catalog of the early-life human skin microbiome, expanding diversity and improving classification rates using metagenomic data from infants and their mothers.

Genome biology · Nov 9, 2023Peer-reviewedGenomics

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Alexander Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen M. L. Tan, Kevin Huynh, Corey Giles, Mei Ding, Gerard Wong, Fabian K. P. Yap, Kok Hian Tan, , Neerja Karnani

The paper maps the developmental and intergenerational changes in the human circulatory lipidome and identifies lipid signatures associated with obesity risk in mothers and offspring.

bioRxiv · Apr 23, 2021 · PreprintSystems Biology

Influence of fecal collection conditions and 16S rRNA gene sequencing protocols at two centers on human gut microbiota analysis

Jocelyn Sietsma Penington, Megan A. S. Penno, Katrina Ngui, Nadim J. Ajami, Alexandra J. Roth‐Schulze, Stephen Wilcox, Esther Bandala‐Sanchez, John M. Wentworth, Simon Charles Barry, Cheryl Y. Brown, Jennifer Couper, Joseph F. Petrosino, Anthony T. Papenfuss, Leonard C. Harrison, ENDIA Study Group*, , Peter Vuillermin

This study evaluates how fecal collection conditions and 16S rRNA sequencing protocols affect gut microbiome analysis across two centers, finding that center-specific differences outweigh collection method variations.

Scientific Reports · Mar 6, 2018Peer-reviewedBioinformatics