Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson's disease
Janelle Drouin‐Ouellet, Karolina Pircs, Emilie M. Legault, Marcella Birtele, Fredrik Nilsson, Shelby Shrigley, Maria Pereira, Petter Storm, Yogita Sharma, Romina Vuono, Thomas B. Stoker, Johan Jakobsson, Roger A. Barker, Malin Parmar
This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.
bioRxiv · Apr 23, 2021 · PreprintNeuroscience