Author

Emilie M. Legault

Université de Montréal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Janelle Drouin‐OuelletiD· 4 shared Roger A. BarkeriD· 3 shared Karolina PircsiD· 2 shared Ádám PapiD· 1 shared Adriaan MerlevedeiD· 1 shared Ágnes VargaiD· 1 shared Andrew S. Park· 1 shared Anna Anoir AbbasiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Janelle Drouin‐OuelletORCID

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Author profile →

4 papers

Recent·Most cited

Decline in mitochondrial health and lysosomal acidification in human neurons during normal aging

Emilie M. Legault, Juan Pablo Izabal Gamez, Janelle Drouin‐Ouellet

This study investigates age-related mitochondrial impairments and mitophagy defects in human neurons using direct reprogramming and imaging.

bioRxiv · Sep 17, 2026 · PreprintNeuroscience

Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons

Lea Danics, Chandramouli Muralidharan, Ágnes Varga, Melinda Rezeli, Jeovanis Gil, Anna Anoir Abbas, Ádám Pap, Andrew S. Park, Marcell Cserhalmi, Emilie M. Legault, Ármin Sőth, Dorina Jamniczky, Roland Zsoldos, Roger A. Barker, Gergely Róna, , Karolina Pircs

The paper identifies phosphoproteomic changes in Huntington's disease patient-derived neurons, revealing dysregulated post-translational modifications and potential compensatory mechanisms.

Cellular & Molecular Biology Letters · Jun 2, 2026Peer-reviewedNeuroscience

Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson's disease

Janelle Drouin‐Ouellet, Karolina Pircs, Emilie M. Legault, Marcella Birtele, Fredrik Nilsson, Shelby Shrigley, Maria Pereira, Petter Storm, Yogita Sharma, Romina Vuono, Thomas B. Stoker, Johan Jakobsson, Roger A. Barker, Malin Parmar

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

bioRxiv · Apr 23, 2021 · PreprintNeuroscience

A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming

Adriaan Merlevede, Emilie M. Legault, Viktor Drugge, Roger A. Barker, Janelle Drouin‐Ouellet, Victor Olariu

This study develops a quantitative model of gene regulatory interactions in neuronal reprogramming, showing that PTB and nPTB interactions are critical for predicting reprogramming outcomes.

Scientific Reports · Jan 15, 2021Peer-reviewedSystems Biology