Fredrik Nilsson

This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.