James G. Burchfield

Systems genetics identifies ETS1 as a stress-dependent regulator of adipocyte insulin action and heme-iron homeostasis

ThunderBolt: An interactive data sharing and analysis platform for large-omics experiments

ThunderBolt provides an interactive web platform for analyzing large proteomics datasets through guided exploration, preprocessing, and statistical analysis.

SnapKin: a snapshot deep learning ensemble for kinase-substrate prediction from phosphoproteomics data

The paper develops SnapKin, a deep learning ensemble model for kinase-substrate prediction from phosphoproteomics data, achieving the best performance in this task.

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

This study uses phosphoproteomics to show that insulin resistance involves rewired signaling networks and widespread dysregulation of GSK3 activity.

Deep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots

The paper compares proteomics profiles of subcutaneous and visceral adipose tissue in mice to identify depot-specific differences and responses to diet.

Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis

The paper introduces an autoencoder-based cluster ensemble framework for scRNA-seq data to improve cell type-specific clustering.