In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors
Qi Liu, Peixin Amy Chen, Esha Urs, Shimin Zhang, Maya M. Arce, Charlotte H. Wang, Zhongmei Li, Jin Seo, Nupura Kale, Taylor N. LaFlam, Fanglue Peng, Eric Shifrut, Greg M. Allen, Justin Eyquem, Katherine Cynthia Fuh, , Julia C. Carnevale
This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.
bioRxiv · Sep 23, 2025 · PreprintImmunology