This study examines the effects of RBM20-R636Q mutation on atrial electrophysiology and evaluates SGLT inhibitors as potential therapeutics for atrial remodeling and arrhythmias.

bioRxiv · Mar 17, 2026 · PreprintMolecular Biology

Enhancer RNA transcriptome-wide association study reveals an atlas of pan-cancer susceptibility eRNAs

Wenyan Chen, Zeyang Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yinuo Wang, Yangmei Qin, Xixian Ma, Yunbo Qiao, Lei Li

This study identifies eRNA-QTLs and susceptibility eRNAs across 23 cancer types, revealing new cancer susceptibility genes through eRNA-based transcriptome-wide association.

medRxiv · Feb 29, 2024 · PreprintGenetic & Genomic Medicine

Rnf20 shapes the endothelial control of heart morphogenesis and function

Linda Kessler, Rui Gao, Nalan Tetik-Elsherbiny, Olga Lityagina, Azhar Zhailauova, Yonggang Ren, Felix A. Trogisch, Julio Cordero, Yanliang Dou, Yinuo Wang, Evgeny Chichelnitskiy, Joscha A. Kraske, Patricia Laura Schäfer, Chi Chung Wu, Guillermo Barreto, , Gergana D. Dobreva

This study identifies Rnf20's role in regulating cardiac morphogenesis and function through endothelial mechanisms, revealing its impact on extracellular matrix dynamics and angiocrine signaling.

bioRxiv · Sep 16, 2022 · PreprintDevelopmental Biology