Yonggang Ren

Rnf20 shapes the endothelial control of heart morphogenesis and function

This study identifies Rnf20's role in regulating cardiac morphogenesis and function through endothelial mechanisms, revealing its impact on extracellular matrix dynamics and angiocrine signaling.

Dysfunction of an energy sensor NFE2L1 triggers uncontrollable AMPK signal and glucose metabolism reprogramming

This study shows that NFE2L1 dysfunction leads to AMPK-driven glucose metabolism reprogramming and mitochondrial damage in liver cancer.

Efficient replacement of long DNA fragments via non-homologous end joining at non-doding regions

This paper introduces an efficient method for genomic DNA replacement in zebrafish using NHEJ-mediated repair at non-coding regions, showing higher efficiency than HR/HDR.

Oncogenic activation of Nrf2 by specific knockout of Nrf1α that acts as a dominant tumor repressor

This study shows that Nrf1 knockout leads to Nrf2 hyperactivation, promoting hepatoma, and reveals a feedback loop between Nrf1 and Nrf2 in tumor suppression.