Chalmers Chi Cheng Chau

Single molecule nanopore sensing across a liquid-solid interface

This paper demonstrates single-molecule nanopore sensing using a solid polymer electrolyte instead of liquid electrolytes, enhancing sensitivity and enabling robust, portable sensing platforms.

Empirical Validation of Composite Fractional Noise Models in Nanopore Signals

This study empirically validates a composite fractional noise model for nanopore signals across diverse experimental conditions, showing it accurately captures noise structure and separates deterministic from stochastic components.

Visualizing and Quantifying microRNA Induced DNA Origami Separation at the Nanoscale

This paper presents a method using DNA origami disassembly driven by miRNA to detect small RNA, showing robust detection in RNAse-containing environments.

Buffer-dependent conformational dynamics of α-synuclein revealed by nanopipette electrospray ionisation ion mobility mass spectrometry

This study uses nanopipette electrospray ionisation ion mobility mass spectrometry to investigate how buffer conditions affect α-synuclein conformational dynamics.

Solid-State Nanopore Real Time Assay for Monitoring Cas9 Endonuclease Reactivity

This paper introduces a polymer electrolyte solid-state nanopore method to monitor endonuclease activity at physiological salt conditions, demonstrating real-time detection of restriction enzyme and CRISPR-Cas9 RNP cleavage.

Single Cell Track and Trace: live cell labelling and temporal transcriptomics via nanobiopsy.

This paper introduces a method to profile the transcriptome of live cells over time, showing treatment induces transcriptionally stable cells in glioblastoma.