Author

N. de Isla

Centre National de la Recherche ScientifiqueORCID 0000-0002-6701-3485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ahmed B Abdelwahab· 1 shared Aleksander Salwiński· 1 shared Alizée Etlicher· 1 shared David MouliniD· 1 shared Diana G. Rogel-AyalaiD· 1 shared Frédéric BourgaudiD· 1 shared Gaël JalceiD· 1 shared Gergana D. DobrevaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Ahmed B Abdelwahab

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The Mitochondria-Modulating Small Molecule TEM1657 Suppresses NFKBIZ Pathway and Resolves Th17-Driven Psoriatic Inflammation

Preeti Gautam, Aleksander Salwiński, Ahmed B Abdelwahab, Gaël Jalce, Laura Boulangé, Jessica Bettinger, Jordan Brouard, Alizée Etlicher, Romain Perouf, Julia Halper, Marie Millard, N. de Isla, Paul Hannewald, Jean-Francois GINGLINGER, Marie-Therese RUBIO, , David Moulin

The paper identifies TEM1657, a small molecule that modulates mitochondria and suppresses NFKBIZ pathway to resolve Th17-driven psoriatic inflammation.

bioRxiv · Oct 10, 2026 · PreprintImmunology

Cell-specific FUS loss enhances ageing-associated transcriptional elongation in lung fibrosis

Diana G. Rogel-Ayala, Julio Cordero, Héctor Aguirre‐Alarcón, Karla Rubio, Guruprasadh Swaminathan, Naceur Charif, N. de Isla, Witold G. Szymanski, Gowthami Kolluru Venkataswamy Reddy, Peter Braubach, Samina Mahmood, Stefan Guenther (5992991), Miguel N. Rivera, Johannes Graumann, Thomas W Braun, , Guillermo Barreto

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

bioRxiv · Oct 9, 2026 · PreprintMolecular Biology