Author

Pablo A. Alvarez

University of California, Los AngelesORCID 0000-0002-0079-3392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

Mehdi BouhaddouiD· 2 shared Melody M. H. LiiD· 2 shared Prashant KaushaliD· 2 shared Alexander HoffmanniD· 1 shared Angélica Medina· 1 shared Anne K. ZaissiD· 1 shared April D. PyleiD· 1 shared Ashley Tang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Mehdi BouhaddouORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

Zhenlan Yao, Pablo A. Alvarez, Carolina Chavez, Yennifer Delgado, Prashant Kaushal, David Austin, Qian Li, Yanying Yu, Anne K. Zaiss, Vaithilingaraja Arumugaswami, Qiang Ding, Jeffrey J. Hsu, Robert D. Damoiseaux, Hector C. Aguilar, Mehdi Bouhaddou, , Melody M. H. Li

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

Science Advances · Aug 5, 2026Peer-reviewedMicrobiology

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion

Pablo A. Alvarez, Ashley Tang, Doug Winters, Prashant Kaushal, Angélica Medina, Marta Nieto, Karolina Elżbieta Kaczor‐Urbanowicz, Faith St. Amant, Bryan Ramirez Reyes, Robyn M. Kaake, Oliver I. Fregoso, April D. Pyle, Mehdi Bouhaddou, Hengli Tang, Melody M. H. Li

This study identifies SLC2A3 as a key factor for Old World alphavirus neuroinvasion through BBB infection, revealing a conserved mechanism across multiple viruses.

Cell Reports · Sep 23, 2025Peer-reviewedMicrobiology