Matthieu J. Caron

SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans

This study identifies two distinct SIN3 complexes in C. elegans that regulate germline gene expression and fertility, revealing their role in X-linked gene silencing.

Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans

This study shows that reduced H3K4 methylation in C. elegans shortens lifespan and reduces fertility, contradicting previous findings that suggested H3K4 methylation extends lifespan.

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3 HDAC complex

The paper identifies a physical and functional interaction between CFP-1 and the Sin3 HDAC complex in C. elegans, showing their coordinated regulation of gene expression.