Dong Yan

This study identifies a signaling cascade involving IDR-1 and RBM-42 that promotes dendrite regeneration through RNA-binding protein nuclear export and local translation.

The paper identifies a novel neuron-glia communication mechanism involving heat shock proteins transmitted via extracellular vesicles, which activate glial pathways to protect against aging-related decline.

The paper shows that transposon expansions in Caenorhabditis nematodes rewired germline transcriptional regulation, with one third of germline-specific promoters co-opted from MITEs.

The paper introduces ARC-C, a method for high-resolution mapping of regulatory element interactions and genome architecture in C. elegans, identifying ~15,000 interactions and revealing domain-level organization.

The paper shows that DREAM complex represses distinct gene targets in C. elegans through cooperation with different THAP domain proteins, LIN-36 and LIN-15B, which use separate mechanisms.

The paper identifies a physical and functional interaction between CFP-1 and the Sin3 HDAC complex in C. elegans, showing their coordinated regulation of gene expression.

The paper maps regulatory elements across C. elegans development and ageing, identifying promoters and enhancers and showing their dynamic accessibility linked to developmental processes.

The paper shows that C. elegans heterochromatin proteins collaborate with piRNA and nuclear RNAi pathways to silence repetitive elements and prevent germline stress.