This paper calibrates Lennard-Jones parameters for silver(I) ions in the CHARMM36m force field to accurately model their interaction with amino acid residues and peptides.

Biophysica · Feb 25, 2025Peer-reviewedBiophysics

A monogenic and fast-responding Light-Inducible Cre recombinase as a novel optogenetic switch

Hélène Duplus‐Bottin, Martin Spichty, Gérard Triqueneaux, Christophe Place, Philippe Emmanuel Mangeot, Théophile Ohlmann, Franck Vittoz, Gaël Yvert

The paper develops LiCre, a fast-responding light-inducible Cre recombinase, and demonstrates its efficiency in yeast and human cells.

eLife · Feb 23, 2021Peer-reviewedSynthetic Biology

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3 HDAC complex

Flore Beurton, Przemysław Stempor, Matthieu J. Caron, Alex Appert, Dong Yan, Ron A.-J. Chen, David Cluet, Yohann Couté, Marion Herbette, Ni Huang, Hélène Polvèche, Martin Spichty, Cécile Bedet, Julie Ahringer, Francesca Palladino

The paper identifies a physical and functional interaction between CFP-1 and the Sin3 HDAC complex in C. elegans, showing their coordinated regulation of gene expression.

Nucleic Acids Research · Oct 3, 2019Peer-reviewedGenomics

Assigning Function To Natural Allelic Variation Via Dynamic Modeling Of Gene Network Induction

Magali Richard, Florent Chuffart, Hélène Duplus‐Bottin, Fanny Pouyet, Martin Spichty, Etienne Fulcrand, Marianne Entrevan, Audrey Barthelaix, Michael Springer, Daniel Jost, Gaël Yvert

The paper uses dynamic modeling of gene networks to interpret natural DNA variants by personalizing model parameters based on genotype, revealing how variants affect molecular regulation in yeast.

Molecular Systems Biology · Jan 1, 2018Peer-reviewedSystems Biology