Yiran Hou

Regenerative epithelial spike cells instruct immune niche homeostasis in zebrafish fin epidermis

The paper identifies a novel epithelial cell type in zebrafish fins, spike cells, and shows their role in maintaining immune cell niche homeostasis through interactions with mpeg1+ immune cells.

Fibroblast response to burn injury in larval zebrafish mirrors developmental maturation and is inhibited by infiltrating neutrophils

Vimentin-driven maturation of col1a1a-positive fibroblasts after larval zebrafish burn parallels fin development, but prolonged neutrophil presence delays fibroblast maturation and organized collagen regrowth.

The axillary lymphoid organ - an external, experimentally accessible immune organ in the zebrafish

The paper identifies a new external immune organ in zebrafish, the axillary lymphoid organ, suitable for live imaging of immune cell dynamics.

Live imaging in zebrafish reveals tissue-specific strategies for amoeboid migration

The paper uses live imaging in zebrafish to show T cells adapt their migration strategies based on tissue-specific geometries, using different actin structures in different environments.

Isotonic medium treatment limits burn wound microbial colonization and improves tissue repair

The paper shows isotonic medium treatment reduces epithelial damage spread and microbial colonization in burn wounds in larval zebrafish and human skin.

Real time imaging reveals a role for macrophage protrusive motility in melanoma invasion

This study uses real-time imaging in zebrafish to show that macrophage protrusive motility, regulated by Rac2, influences melanoma invasion.

Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.