Author

Dean G. Brown

AstraZeneca (United States)ORCID 0000-0002-7130-3928Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron D. GitleriD· 1 shared Albert KoulmaniD· 1 shared Alice Flynn Ford· 1 shared Andrew Davis· 1 shared Ashkan JavaherianiD· 1 shared Ashmita Baral· 1 shared Benjamin JenkinsiD· 1 shared Bo Lim Lee· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Aaron D. GitlerORCID

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2 papers

Recent·Most cited

Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target

Maria Claudia Caiazza, Janine Brandes, Elizabeth R. Barrow, Ricardo Márquez-Gómez, Dean G. Brown, Benjamin Jenkins, Uroosa Chughtai, William McGuinness, Stewart W. Humble, Parnaz Sharifi, Johanna L. Hoffmann, Matthieu Trigano, Albert Koulman, Ian Gurrell, Andrew Davis, , Richard Wade‐Martins

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

bioRxiv · Nov 1, 2026 · PreprintNeuroscience

Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.

Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee, Úna Chan, Jocelyn C. Mauna, Korrie L. Mack, Bradley Class, Thomas A. Ollerhead, Alice Flynn Ford, Edward M. Barbieri, Ryan R. Cupo, Lauren E. Drake, Joshua L. Smalley, Yuan-Ta Lin, , James Shorter

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology